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Ro 04-6790
Ro 04-6790 is a drug, developed by Hoffmann–La Roche, which has applications in scientific research. It acts as a potent and selective receptor antagonist for the 5-HT6 serotonin receptor subtype, with little or no affinity at other receptors. In common with other drugs of this class,〔Fone KC. An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function. ''Neuropharmacology''. 2008 Nov;55(6):1015-22. PMID 18655798〕 Ro 04-6790 has nootropic effects in animals,〔King MV, Spicer CH, Sleight AJ, Marsden CA, Fone KC. Impact of regional 5-HT depletion on the cognitive enhancing effects of a typical 5-ht(6) receptor antagonist, Ro 04-6790, in the Novel Object Discrimination task. ''Psychopharmacology (Berlin)''. 2008 Oct 7. PMID 18839151〕 and reduces the amnesia produced by memory-impairing drugs such as dizocilpine〔Pitsikas N, Zisopoulou S, Pappas I, Sakellaridis N. The selective 5-HT(6) receptor antagonist Ro 04-6790 attenuates psychotomimetic effects of the NMDA receptor antagonist MK-801. ''Behavioural Brain Research''. 2008 Apr 9;188(2):304-9. PMID 18164078〕 and scopolamine.〔Woolley ML, Marsden CA, Sleight AJ, Fone KC. Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro 04-6790. ''Psychopharmacology (Berlin)''. 2003 Dec;170(4):358-67. PMID 13680084〕
==References==
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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